Overview
The TPHA test detects treponemal antibodies and is used to confirm syphilis exposure after a reactive nontreponemal screen.
What it detects
Treponemal antibodies associated with syphilis.
Sample type
Blood sample.
When it may be appropriate
Confirmatory testing after reactive VDRL or RPR.
Window period considerations
May take time to become positive after infection.
Test limitations
A positive result may indicate current or past infection and does not distinguish treated disease.
Interpretation basics
Positive TPHA supports syphilis exposure; combine with nontreponemal titer and clinical assessment.
Follow-up recommendations
Determine stage and treatment history; monitor with nontreponemal titers.
Key points
- Treponemal confirmation
- May remain positive after treatment
- Used with VDRL/RPR
- Timing matters
When to seek care
- Reactive syphilis screen
- Syphilis diagnosis support
- Partner evaluation