Overview
Syphilis treatment depends on stage, symptoms and prior treatment. Penicillin-based therapy is commonly used, but medical supervision and follow-up serology are essential.
Treatment approach
Stage-appropriate antibiotic therapy after diagnosis.
Common management options
- Benzathine penicillin for most stages
- Alternative regimens for penicillin allergy in selected cases
- Neurosyphilis requires specialist-directed therapy
Medical supervision
Treatment should be prescribed and monitored by a clinician. Allergies, pregnancy and neurologic symptoms affect choices.
Partner considerations
Partner evaluation depends on stage and timing; untreated partners may need treatment.
Follow-up
Nontreponemal titers are often used to monitor response over time.
Key points
- Stage guides treatment
- Penicillin is standard for many cases
- Follow-up serology matters
- Partner care may be needed
When to seek care
- Positive syphilis test
- Genital ulcer or rash
- Partner diagnosis